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Indication & Dosage |
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| Oral |
| PATIENTS WITH HAEMOPHILIA UNDERGOING DENTAL EXTRACTION |
| Adult:
Initially, 6 g immediately after the procedure, followed by 6 g every 6 hr for up to 10 days. |
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| Oral |
| TREATMENT AND PROPHYLAXIS OF HAEMORRHAGE |
| Adult:
Initially, 4-5 g, followed by 1-1.25 g/hr for about 8 hr or until bleeding has been controlled. Max: 24 g in 24 hr. |
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| Intravenous |
| TREATMENT AND PROPHYLAXIS OF HAEMORRHAGE |
| Adult:
Initially, 4-5 g, followed by 1-1.25 g/hr for about 8 hr or until bleeding has been controlled. Max: 24 g in 24 hr. |
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| Administration |
May be taken with or without food. (May be taken w/ meals to prevent GI upset.) |
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| Precautions |
Renal or cardiac disorders. Urinary tract bleeding, haematuria of upper urinary tract origin; veno-occlusive hepatic disease, skeletal myopathy, neonates. Monitor creatinine phosphokinase. Avoid admin with factor IX complex concentrates. Pregnancy and lactation. |
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Potentially Life-threatening
Adverse Drug Reactions |
Oedema, headache, malaise, allergic and anaphylactic reactions, anaphylaxis, bradycardia, hypotension, peripheral ischaemia, thrombosis, abdominal pain, diarrhoea, nausea, vomiting, agranulocytosis, coagulation disorder, leukopaenia, thrombocytopaenia, increased CPK, muscle damage, myalgia, myopathy, myositis, rhabdomyolysis, confusion, convulsions, delirium, dizziness, hallucinations, intracranial hypertension, stroke, syncope, dyspnoea, nasal congestion, pulmonary embolism, pruritus, rash, tinnitus, decreased vision, watery eyes, increased BUN, dry ejaculation. |
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| Adverse Drug Reactions |
Cardiac and hepatic damage. |
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| Interactions |
Increased risk of hypercoagulability with OC and oestrogens. |
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